What is Oligoclonal Antibody?
Oligoclonal Antibodies are innovative products that combine the advantages of monoclonal and polyclonal antibodies. They are composed of two or more monoclonal antibodies (mAbs) that are mixed in known proportions. The monoclonal antibodies are fully characterized and target different epitopes of the same antigen.
Advantages of Oligoclonal Antibodies
- High Reproducibility：Since Oligoclonal Antibodies are made from well-characterized and fully sequenced monoclonals, the product inherits the batch-to-batch stability of these components. The defined and controllable formulation of Oligoclonal Antibodies guarantees consistent performance across experiments.
- High Specificity：Each monoclonal antibody in the oligoclonal mixture targets a specific epitope of the antigen, thereby minimizing the risk of nonspecific binding.
- High Sensitivity：Oligoclonal Antibodies bind to multiple epitopes simultaneously, increasing sensitivity in detection and enabling analysis of low-abundance targets.
- Low Background：Compared to polyclonal antibodies, Oligoclonal Antibodies reduce background noise caused by nonspecific binding while retaining the sensitivity advantage, resulting in a higher signal-to-noise ratio that is ideal for various detection applications.
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